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Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
Cleavage and release (shedding) of membrane proteins is a critical regulatory step in many normal and pathological processes. Evidence suggests that the antiaging transmembrane protein Klotho (KL) is shed from the cell surface by proteolytic cleavage. In this study, we attempted to identify the enzy...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2148378/ https://ncbi.nlm.nih.gov/pubmed/18056631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709805104 |
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