ADAM10 Releases a Soluble Form of the GPNMB/Osteoactivin Extracellular Domain with Angiogenic Properties

BACKGROUND: Glycoprotein non-metastatic melanoma protein B (GPNMB)/Osteoactivin (OA) is a transmembrane protein expressed in approximately 40–75% of breast cancers. GPNMB/OA promotes the migration, invasion and metastasis of breast cancer cells; it is commonly expressed in basal/triple-negative brea...

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Autors principals: Rose, April A. N., Annis, Matthew G., Dong, Zhifeng, Pepin, Francois, Hallett, Michael, Park, Morag, Siegel, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919417/
https://ncbi.nlm.nih.gov/pubmed/20711474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012093
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