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N-Terminal Cleavage and Release of the Ectodomain of Flt1 Is Mediated via ADAM10 and ADAM 17 and Regulated by VEGFR2 and the Flt1 Intracellular Domain

Flt is one of the cell surface VEGF receptors which can be cleaved to release an N-terminal extracellular fragment which, like alternately transcribed soluble Flt1 (sFlt1), can antagonize the effects of VEGF. In HUVEC and in HEK293 cells where Flt1 was expressed, metalloprotease inhibitors reduced F...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Raikwar, Nandita S., Liu, Kang Z., Thomas, Christie P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227870/
https://ncbi.nlm.nih.gov/pubmed/25387128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112794
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