ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Yang, Jinling, LeBlanc, Michelle E., Cano, Issahy, Saez-Torres, Kahira L., Saint-Geniez, Magali, Ng, Yin-Shan, D'Amore, Patricia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212652/
https://ncbi.nlm.nih.gov/pubmed/32193206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011192
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