Requirement for T-bet in the aberrant differentiation of unhelped memory CD8(+) T cells

Immunity to intracellular pathogens requires dynamic balance between terminal differentiation of short-lived, cytotoxic effector CD8(+) T cells and self-renewal of central–memory CD8(+) T cells. We now show that T-bet represses transcription of IL-7Rα and drives differentiation of effector and effec...

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Detalhes bibliográficos
Main Authors: Intlekofer, Andrew M., Takemoto, Naofumi, Kao, Charlly, Banerjee, Arnob, Schambach, Felix, Northrop, John K., Shen, Hao, Wherry, E. John, Reiner, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118697/
https://ncbi.nlm.nih.gov/pubmed/17698591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070841
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