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Anomalous Type 17 Response to Viral Infection by CD8(+) T Cells Lacking T-bet and Eomesodermin
When intracellular pathogens invade mammalian hosts, naïve CD8(+) T cells differentiate into cytotoxic killers, which lyse infected target cells and secrete cytokines that activate intracellular microbicides. We now show that CD8(+) T cells deficient in the transcription factors T-bet and eomesoderm...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2807624/ https://ncbi.nlm.nih.gov/pubmed/18635804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1159806 |
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