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Lymphoproliferation Caused by Fas Deficiency Is Dependent on the Transcription Factor Eomesodermin
A hallmark of autoimmune lymphoproliferative syndrome (ALPS), caused by mutation of the Fas death receptor, is massive lymphadenopathy from aberrant expansion of CD4(−)CD8(−) (double-negative, DN) T cells. Eomesodermin (Eomes) is a member of the T-box family of transcription factors and plays critic...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997140/ https://ncbi.nlm.nih.gov/pubmed/21076068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003193 |
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