Lymphoproliferation Caused by Fas Deficiency Is Dependent on the Transcription Factor Eomesodermin

A hallmark of autoimmune lymphoproliferative syndrome (ALPS), caused by mutation of the Fas death receptor, is massive lymphadenopathy from aberrant expansion of CD4(−)CD8(−) (double-negative, DN) T cells. Eomesodermin (Eomes) is a member of the T-box family of transcription factors and plays critic...

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Hlavní autoři: Kinjyo, Ichiko, Gordon, Scott M., Intlekofer, Andrew M., Dowdell, Kennichi, Mooney, Erin C., Caricchio, Roberto, Grupp, Stephan A., Teachey, David T., Rao, V. Koneti, Lindsten, Tullia, Reiner, Steven L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997140/
https://ncbi.nlm.nih.gov/pubmed/21076068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003193
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