Valproic Acid (VPA), a Histone Deacetylase (HDAC) Inhibitor, Diminishes Lymphoproliferation in the Fas Deficient MRL/lpr−/− Murine Model of Autoimmune Lymphoproliferative Syndrome (ALPS)

OBJECTIVE: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of apoptosis, often presenting in childhood. Similarly, MRL/lpr−/− mice homozygous for Fas mutations develop an ALPS-like disease with autoimmunity, lymphadenopathy, splenomegaly, and expansion of double negative T (DNT) cells....

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Главные авторы: Dowdell, Kennichi C, Pesnicak, Lesley, Hoffmann, Victoria, Steadman, Kenneth, Remaley, Alan T., Cohen, Jeffrey I., Straus, Stephen E, Rao, V. Koneti
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693256/
https://ncbi.nlm.nih.gov/pubmed/19217201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.12.002
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