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Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

Expression of autoimmune regulator (Aire) by thymic medullary epithelial cells (MECs) is critical for central tolerance of self. To explore the mechanism by which such a rare cell population imposes tolerance on the large repertoire of differentiating thymocytes, we examined the proliferation and tu...

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Autors principals: Gray, Daniel, Abramson, Jakub, Benoist, Christophe, Mathis, Diane
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118482/
https://ncbi.nlm.nih.gov/pubmed/17908938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070795
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