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Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA) in thymic medullary epithelial cells (MECs), driving immunological self-tolerance in differentiating T cells. To elucidate its mechanistic pathways, we examined its transcriptional impact in MECs in vivo...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3258631/ https://ncbi.nlm.nih.gov/pubmed/22203960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119351109 |
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