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Aire controls gene expression in the thymic epithelium with ordered stochasticity
Aire controls immunologic tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire’s specificity, we performed single-cell RNAseq and DNA methylation analysis in Aire-sufficient and...
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| Veröffentlicht in: | Nat Immunol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4632529/ https://ncbi.nlm.nih.gov/pubmed/26237550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3247 |
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