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Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
Both humans and mice with a mutation in the autoimmune regulator (aire) gene develop multiorgan autoimmune disease. Aire was shown to exert its critical function in medullary epithelial cells of the thymus by promoting ectopic expression of peripheral tissue antigens. It was hypothesized that the wi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838644/ https://ncbi.nlm.nih.gov/pubmed/17360567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700259104 |
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