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Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity

Both humans and mice with a mutation in the autoimmune regulator (aire) gene develop multiorgan autoimmune disease. Aire was shown to exert its critical function in medullary epithelial cells of the thymus by promoting ectopic expression of peripheral tissue antigens. It was hypothesized that the wi...

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Bibliografske podrobnosti
Main Authors: Gavanescu, Irina, Kessler, Benedikt, Ploegh, Hidde, Benoist, Christophe, Mathis, Diane
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838644/
https://ncbi.nlm.nih.gov/pubmed/17360567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700259104
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