Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

Aire controls immunologic tolerance by inducing a battery of thymic transcripts encoding proteins characteristic of peripheral tissues. Its unusually broad effect is achieved by releasing RNA polymerase II paused just downstream of transcriptional start sites. We explored Aire’s collaboration with t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yoshida, Hideyuki, Bansal, Kushagra, Schaefer, Uwe, Chapman, Trevor, Rioja, Inmaculada, Proekt, Irina, Anderson, Mark S., Prinjha, Rab K., Tarakhovsky, Alexander, Benoist, Christophe, Mathis, Diane
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538633/
https://ncbi.nlm.nih.gov/pubmed/26216992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512081112
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