Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

Aire controls immunologic tolerance by inducing a battery of thymic transcripts encoding proteins characteristic of peripheral tissues. Its unusually broad effect is achieved by releasing RNA polymerase II paused just downstream of transcriptional start sites. We explored Aire’s collaboration with t...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Yoshida, Hideyuki, Bansal, Kushagra, Schaefer, Uwe, Chapman, Trevor, Rioja, Inmaculada, Proekt, Irina, Anderson, Mark S., Prinjha, Rab K., Tarakhovsky, Alexander, Benoist, Christophe, Mathis, Diane
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538633/
https://ncbi.nlm.nih.gov/pubmed/26216992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512081112
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