Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

Aire controls immunologic tolerance by inducing a battery of thymic transcripts encoding proteins characteristic of peripheral tissues. Its unusually broad effect is achieved by releasing RNA polymerase II paused just downstream of transcriptional start sites. We explored Aire’s collaboration with t...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yoshida, Hideyuki, Bansal, Kushagra, Schaefer, Uwe, Chapman, Trevor, Rioja, Inmaculada, Proekt, Irina, Anderson, Mark S., Prinjha, Rab K., Tarakhovsky, Alexander, Benoist, Christophe, Mathis, Diane
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538633/
https://ncbi.nlm.nih.gov/pubmed/26216992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512081112
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