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The transcriptional regulator Aire binds to and activates super-enhancers

Aire is a transcription factor that controls T cell tolerance by inducing the expression of a large repertoire of genes specifically in thymic stromal cells. It interacts with scores of protein partners of diverse functional classes. Here we showed that Aire and some of its partners, notably those i...

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Foilsithe in:Nat Immunol
Main Authors: Bansal, Kushagra, Yoshida, Hideyuki, Benoist, Christophe, Mathis, Diane
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310976/
https://ncbi.nlm.nih.gov/pubmed/28135252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3675
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