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Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance
Aire impacts immunological tolerance by regulating the expression of a large set of genes in thymic medullary epithelial cells, thereby controlling the repertoire of self-antigens encountered by differentiating thymocytes. Both humans and mice lacking Aire develop multiorgan autoimmunity. Currently,...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562810/ https://ncbi.nlm.nih.gov/pubmed/23319629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222023110 |
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