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The variable immunological self: Genetic variation and nongenetic noise in Aire-regulated transcription

The Aire transcription factor plays an important role in immunological self-tolerance by mediating the ectopic expression of peripheral self-antigens by thymic medullary epithelial cells (MECs), and the deletion of thymocytes that recognize them. In Aire-deficient humans or mice, central tolerance i...

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Detalhes bibliográficos
Main Authors: Venanzi, Emily S., Melamed, Rachel, Mathis, Diane, Benoist, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572942/
https://ncbi.nlm.nih.gov/pubmed/18838677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808070105
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