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Transcriptional impact of Aire varies with cell type

Aire promotes T cell tolerance by inducing the expression of a broad swath of genes encoding peripheral tissue antigens (PTAs) in medullary epithelial cells (MECs) of the thymus. The exact mechanism used in inducing this ectopic transcription remains obscure. To address this issue, we generated tran...

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Hlavní autoři: Guerau-de-Arellano, Mireia, Mathis, Diane, Benoist, Christophe
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544570/
https://ncbi.nlm.nih.gov/pubmed/18780794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806616105
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