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Transcriptional impact of Aire varies with cell type
Aire promotes T cell tolerance by inducing the expression of a broad swath of genes encoding peripheral tissue antigens (PTAs) in medullary epithelial cells (MECs) of the thymus. The exact mechanism used in inducing this ectopic transcription remains obscure. To address this issue, we generated tran...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2544570/ https://ncbi.nlm.nih.gov/pubmed/18780794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806616105 |
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