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Transcriptional impact of Aire varies with cell type
Aire promotes T cell tolerance by inducing the expression of a broad swath of genes encoding peripheral tissue antigens (PTAs) in medullary epithelial cells (MECs) of the thymus. The exact mechanism used in inducing this ectopic transcription remains obscure. To address this issue, we generated tran...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2544570/ https://ncbi.nlm.nih.gov/pubmed/18780794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806616105 |
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