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Transcriptional impact of Aire varies with cell type

Aire promotes T cell tolerance by inducing the expression of a broad swath of genes encoding peripheral tissue antigens (PTAs) in medullary epithelial cells (MECs) of the thymus. The exact mechanism used in inducing this ectopic transcription remains obscure. To address this issue, we generated tran...

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書誌詳細
主要な著者: Guerau-de-Arellano, Mireia, Mathis, Diane, Benoist, Christophe
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544570/
https://ncbi.nlm.nih.gov/pubmed/18780794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806616105
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