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B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients

Autoimmune regulator (Aire)-deficient mice and humans have circulating autoantibodies against a multitude of organs and multiorgan autoinflammatory infiltrates. It is not known to what extent autoantibodies or their source, B lymphocytes, are required for disease onset or progression. We show in thi...

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Bibliographic Details
Main Authors: Gavanescu, Irina, Benoist, Christophe, Mathis, Diane
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529049/
https://ncbi.nlm.nih.gov/pubmed/18755889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806874105
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