Cargando...

How defects in central tolerance impinge on a deficiency in regulatory T cells

Both central (thymic) and peripheral (nonthymic) mechanisms are important for the induction and maintenance of T cell tolerance. Mice with a defect in Foxp3, required for the generation and activity of CD4(+)CD25(+) regulatory T cells, exhibit massive lymphoproliferation and severe inflammatory infi...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Chen, Zhibin, Benoist, Christophe, Mathis, Diane
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253589/
https://ncbi.nlm.nih.gov/pubmed/16203996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507014102
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!