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How defects in central tolerance impinge on a deficiency in regulatory T cells
Both central (thymic) and peripheral (nonthymic) mechanisms are important for the induction and maintenance of T cell tolerance. Mice with a defect in Foxp3, required for the generation and activity of CD4(+)CD25(+) regulatory T cells, exhibit massive lymphoproliferation and severe inflammatory infi...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1253589/ https://ncbi.nlm.nih.gov/pubmed/16203996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507014102 |
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