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How defects in central tolerance impinge on a deficiency in regulatory T cells

Both central (thymic) and peripheral (nonthymic) mechanisms are important for the induction and maintenance of T cell tolerance. Mice with a defect in Foxp3, required for the generation and activity of CD4(+)CD25(+) regulatory T cells, exhibit massive lymphoproliferation and severe inflammatory infi...

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Hlavní autoři: Chen, Zhibin, Benoist, Christophe, Mathis, Diane
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253589/
https://ncbi.nlm.nih.gov/pubmed/16203996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507014102
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