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Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
Aire is an important regulator of immunological tolerance, operating in a minute subset of thymic stromal cells to induce transcripts encoding peptides that guide T-cell selection. Expression of Aire during a perinatal age-window is necessary and sufficient to prevent the multi-organ autoimmunity ch...
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| 出版年: | Science |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4710357/ https://ncbi.nlm.nih.gov/pubmed/25791085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa7017 |
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