Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

Aggregate-like biomolecular assemblies are emerging as new conformational states with functionality. Aire, a transcription factor essential for central T cell tolerance, forms large aggregate-like assemblies visualized as nuclear foci. Here we demonstrate that Aire utilizes its caspase activation re...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Huoh, Yu-San, Wu, Bin, Park, Sehoon, Yang, Darren, Bansal, Kushagra, Greenwald, Emily, Wong, Wesley P., Mathis, Diane, Hur, Sun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118133/
https://ncbi.nlm.nih.gov/pubmed/32242017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15448-w
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