Lack of Foxp3 function and expression in the thymic epithelium

Foxp3 is essential for the commitment of differentiating thymocytes to the regulatory CD4(+) T (T reg) cell lineage. In humans and mice with a genetic Foxp3 deficiency, absence of this critical T reg cell population was suggested to be responsible for the severe autoimmune lesions. Recently, it has...

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Библиографические подробности
Главные авторы: Liston, Adrian, Farr, Andrew G., Chen, Zhibin, Benoist, Christophe, Mathis, Diane, Manley, Nancy R., Rudensky, Alexander Y.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2007
Предметы:
Brief Definitive Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2137899/
https://ncbi.nlm.nih.gov/pubmed/17353370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062465
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