Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA) in thymic medullary epithelial cells (MECs), driving immunological self-tolerance in differentiating T cells. To elucidate its mechanistic pathways, we examined its transcriptional impact in MECs in vivo...

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Библиографические подробности
Главные авторы: Giraud, Matthieu, Yoshida, Hideyuki, Abramson, Jakub, Rahl, Peter B., Young, Richard A., Mathis, Diane, Benoist, Christophe
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258631/
https://ncbi.nlm.nih.gov/pubmed/22203960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119351109
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