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Prostacyclin-IP signaling and prostaglandin E(2)-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis

Prostaglandin (PG)I(2) (prostacyclin [PGI]) and PGE(2) are abundantly present in the synovial fluid of rheumatoid arthritis (RA) patients. Although the role of PGE(2) in RA has been well studied, how much PGI(2) contributes to RA is little known. To examine this issue, we backcrossed mice lacking th...

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Detalles Bibliográficos
Main Authors: Honda, Tetsuya, Segi-Nishida, Eri, Miyachi, Yoshiki, Narumiya, Shuh
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2006
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118213/
https://ncbi.nlm.nih.gov/pubmed/16446378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051310
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