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Dual roles of PGE(2)-EP4 signaling in mouse experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). Although prostaglandin (PG) concentrations are increased in cerebrospinal fluid of MS patients, the role of PGs in MS is unknown. We examined this issue by subjecting mice deficient in each PG receptor typ...

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Detalhes bibliográficos
Main Authors: Esaki, Yoshiyasu, Li, Youxian, Sakata, Daiji, Yao, Chengcan, Segi-Nishida, Eri, Matsuoka, Toshiyuki, Fukuda, Kazuhiko, Narumiya, Shuh
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901475/
https://ncbi.nlm.nih.gov/pubmed/20566843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915112107
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