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Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

Death by neglect requires that CD4(+)8(+) double-positive (DP) thymocytes avoid cytokine-mediated survival signals, which is presumably why DP thymocytes normally extinguish IL-7R gene expression. We report that DP thymocytes before positive selection (preselection DP thymocytes) fail to transduce I...

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Библиографические подробности
Главные авторы: Yu, Qing, Park, Jung-Hyun, Doan, Loretta L., Erman, Batu, Feigenbaum, Lionel, Singer, Alfred
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118084/
https://ncbi.nlm.nih.gov/pubmed/16390939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051836
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