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Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection
Death by neglect requires that CD4(+)8(+) double-positive (DP) thymocytes avoid cytokine-mediated survival signals, which is presumably why DP thymocytes normally extinguish IL-7R gene expression. We report that DP thymocytes before positive selection (preselection DP thymocytes) fail to transduce I...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118084/ https://ncbi.nlm.nih.gov/pubmed/16390939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051836 |
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