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Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation
During T cell development in the thymus, pre–T cell receptor (TCR) complexes signal CD4(−) CD8(−) (double negative [DN]) thymocytes to differentiate into CD4(+) CD8(+) (double positive [DP]) thymocytes, and they generate such signals without apparent ligand engagements. Although ligand-independent s...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212817/ https://ncbi.nlm.nih.gov/pubmed/15210747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20032204 |
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