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IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt: Impact on Thymocyte Development
Intrathymic T cell development depends on signals transduced by both T cell receptor and cytokine receptors. Early CD4(−)CD8(−) (double negative) thymocytes require interleukin (IL)-7 receptor (IL-7R) signals for survival and proliferation, but IL-7R signals are normally extinguished by the immature...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211960/ https://ncbi.nlm.nih.gov/pubmed/15365098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20032183 |
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