IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt: Impact on Thymocyte Development

Intrathymic T cell development depends on signals transduced by both T cell receptor and cytokine receptors. Early CD4(−)CD8(−) (double negative) thymocytes require interleukin (IL)-7 receptor (IL-7R) signals for survival and proliferation, but IL-7R signals are normally extinguished by the immature...

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Hlavní autoři: Yu, Qing, Erman, Batu, Park, Jung-Hyun, Feigenbaum, Lionel, Singer, Alfred
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2004
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211960/
https://ncbi.nlm.nih.gov/pubmed/15365098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20032183
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