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In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8(+) T Cells

CD4(+)8(+) double positive (DP) thymocytes differentiate into CD4(+) and CD8(+) mature T cells in response to TCR signals. However, TCR signals that are initiated in DP thymocytes are unlikely to persist throughout all subsequent differentiation steps, suggesting that other signals must sustain thym...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yu, Qing, Erman, Batu, Bhandoola, Avinash, Sharrow, Susan O., Singer, Alfred
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193862/
https://ncbi.nlm.nih.gov/pubmed/12591905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021765
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