Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

Receptor subunits for the neurocytokine ciliary neurotrophic factor (CNTF) share sequence similarity with the receptor for leptin, an adipocyte-derived cytokine involved in body weight homeostasis. We report here that CNTF and leptin activate a similar pattern of STAT factors in neuronal cells, and...

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Autori principali: Gloaguen, Isabelle, Costa, Patrizia, Demartis, Anna, Lazzaro, Domenico, Di Marco, Annalise, Graziani, Rita, Paonessa, Giacomo, Chen, Fang, Rosenblum, Charles I., Van der Ploeg, Lex H. T., Cortese, Riccardo, Ciliberto, Gennaro, Laufer, Ralph
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC21071/
https://ncbi.nlm.nih.gov/pubmed/9177239
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