Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity

Disruption of the leptin signaling pathway within the heart causes left ventricular hypertrophy (LVH). Because human obesity is a syndrome of leptin resistance, which is not amenable to leptin treatment, the identification of parallel signal transduction pathways is of potential therapeutic value. C...

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Detalhes bibliográficos
Main Authors: Raju, Shubha V. Y., Zheng, Meizi, Schuleri, Karl H., Phan, Alexander C., Bedja, Djahida, Saraiva, Roberto M., Yiginer, Omer, Vandegaer, Koenraad, Gabrielson, Kathleen L., O’Donnell, Christopher P., Berkowitz, Dan E., Barouch, Lili A., Hare, Joshua M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449674/
https://ncbi.nlm.nih.gov/pubmed/16537512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510460103
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