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Reduced Neuronal Nitric Oxide Synthase Expression Contributes to Cardiac Oxidative Stress and Nitroso-Redox Imbalance in ob/ob Mice
Disruption of leptin signaling in the heart may contribute to obesity-related cardiac disease, as leptin deficient (ob/ob) mice display cardiac hypertrophy, increased cardiac apoptosis and reduced survival. Since leptin maintains a tonic level of neuronal nitric oxide synthase (NOS1) expression in t...
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754218/ https://ncbi.nlm.nih.gov/pubmed/17307368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2006.12.001 |
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