Reduced Neuronal Nitric Oxide Synthase Expression Contributes to Cardiac Oxidative Stress and Nitroso-Redox Imbalance in ob/ob Mice

Disruption of leptin signaling in the heart may contribute to obesity-related cardiac disease, as leptin deficient (ob/ob) mice display cardiac hypertrophy, increased cardiac apoptosis and reduced survival. Since leptin maintains a tonic level of neuronal nitric oxide synthase (NOS1) expression in t...

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Main Authors: Saraiva, Roberto M, Minhas, Khalid M, Zheng, Meizi, Pitz, Eleanor, Treuer, Adriana, Gonzalez, Daniel, Schuleri, Karl H, Vandegaer, Koenraad M, Barouch, Lili A, Hare, Joshua M
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754218/
https://ncbi.nlm.nih.gov/pubmed/17307368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2006.12.001
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