Hydralazine and Organic Nitrates Restore Impaired Excitation-Contraction Coupling by Reducing Calcium Leak Associated with Nitroso-Redox Imbalance

Although the combined use of hydralazine and isosorbide dinitrate confers important clinical benefits in patients with heart failure, the underlying mechanism of action is still controversial. We used two models of nitroso-redox imbalance, neuronal NO synthase-deficient (NOS1(−/−)) mice and spontane...

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Detaylı Bibliyografya
Asıl Yazarlar: Dulce, Raul A., Yiginer, Omer, Gonzalez, Daniel R., Goss, Garrett, Feng, Ning, Zheng, Meizi, Hare, Joshua M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585085/
https://ncbi.nlm.nih.gov/pubmed/23319593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.412130
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