Leptin repletion restores depressed β-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy

Impaired leptin signalling in obesity is increasingly implicated in cardiovascular pathophysiology. To explore mechanisms for leptin activity in the heart, we hypothesized that physiological leptin signalling participates in maintaining cardiac β-adrenergic regulation of excitation–contraction coupl...

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Detalhes bibliográficos
Main Authors: Minhas, Khalid M, Khan, Shakil A, Raju, Shubha VY, Phan, Alexander C, Gonzalez, Daniel R, Skaf, Mike W, Lee, Kwangho, Tejani, Ankit D, Saliaris, Anastasies P, Barouch, Lili A, O'Donnell, Christopher P, Emala, Charles W, Berkowitz, Dan E, Hare, Joshua M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Cell Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464532/
https://ncbi.nlm.nih.gov/pubmed/15760936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.084566
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