Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation

We show that an electric treatment in the form of high-frequency, low-voltage electric pulses can increase more than 100-fold the production and secretion of a recombinant protein from mouse skeletal muscle. Therapeutical erythopoietin (EPO) levels were achieved in mice with a single injection of as...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rizzuto, Gabriella, Cappelletti, Manuela, Maione, Domenico, Savino, Rocco, Lazzaro, Domenico, Costa, Patrizia, Mathiesen, Iacob, Cortese, Riccardo, Ciliberto, Gennaro, Laufer, Ralph, La Monica, Nicola, Fattori, Elena
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26896/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10339602/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.11.6417
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