Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation

We show that an electric treatment in the form of high-frequency, low-voltage electric pulses can increase more than 100-fold the production and secretion of a recombinant protein from mouse skeletal muscle. Therapeutical erythopoietin (EPO) levels were achieved in mice with a single injection of as...

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Bibliographic Details
Main Authors: Rizzuto, Gabriella, Cappelletti, Manuela, Maione, Domenico, Savino, Rocco, Lazzaro, Domenico, Costa, Patrizia, Mathiesen, Iacob, Cortese, Riccardo, Ciliberto, Gennaro, Laufer, Ralph, La Monica, Nicola, Fattori, Elena
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC26896/
https://ncbi.nlm.nih.gov/pubmed/10339602
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