An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus

Helper-dependent adenoviral vectors deleted of all viral coding sequences have shown an excellent gene expression profile in a variety of animal models, as well as a reduced toxicity after systemic delivery. What is still unclear is whether long-term expression and therapeutic dosages of these vecto...

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Detalhes bibliográficos
Main Authors: Maione, Domenico, Rocca, Carlo Della, Giannetti, Patrizia, D'Arrigo, Roberta, Liberatoscioli, Laura, Franlin, Laura L., Sandig, Volker, Ciliberto, Gennaro, La Monica, Nicola, Savino, Rocco
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC33410/
https://ncbi.nlm.nih.gov/pubmed/11353820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101122498
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