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An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus

Helper-dependent adenoviral vectors deleted of all viral coding sequences have shown an excellent gene expression profile in a variety of animal models, as well as a reduced toxicity after systemic delivery. What is still unclear is whether long-term expression and therapeutic dosages of these vecto...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Maione, Domenico, Rocca, Carlo Della, Giannetti, Patrizia, D'Arrigo, Roberta, Liberatoscioli, Laura, Franlin, Laura L., Sandig, Volker, Ciliberto, Gennaro, La Monica, Nicola, Savino, Rocco
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33410/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353820/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.101122498
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