Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies

High avidity and long-lasting autoantibodies to a self-polypeptide (TNF-α) were generated after parenteral vaccination of mice with low doses of virus-like particle–based (VLP-based) vaccines that were constructed by linking mouse TNF-α peptides to the surface of papillomavirus VLPs. High-titer auto...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Chackerian, Bryce, Lowy, Douglas R., Schiller, John T.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11489935/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11849
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