A strong signature of balancing selection in the 5′ cis-regulatory region of CCR5

CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5′ cis-regula...

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Detalhes bibliográficos
Main Authors: Bamshad, Michael J., Mummidi, Srinivas, Gonzalez, Enrique, Ahuja, Seema S., Dunn, Diane M., Watkins, W. Scott, Wooding, Stephen, Stone, Anne C., Jorde, Lynn B., Weiss, Robert B., Ahuja, Sunil K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC124967/
https://ncbi.nlm.nih.gov/pubmed/12149450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162046399
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