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A strong signature of balancing selection in the 5′ cis-regulatory region of CCR5

CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5′ cis-regula...

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Salvato in:
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bamshad, Michael J., Mummidi, Srinivas, Gonzalez, Enrique, Ahuja, Seema S., Dunn, Diane M., Watkins, W. Scott, Wooding, Stephen, Stone, Anne C., Jorde, Lynn B., Weiss, Robert B., Ahuja, Sunil K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124967/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12149450/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162046399
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