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Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies

High avidity and long-lasting autoantibodies to a self-polypeptide (TNF-α) were generated after parenteral vaccination of mice with low doses of virus-like particle–based (VLP-based) vaccines that were constructed by linking mouse TNF-α peptides to the surface of papillomavirus VLPs. High-titer auto...

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Bibliografske podrobnosti
Main Authors: Chackerian, Bryce, Lowy, Douglas R., Schiller, John T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC209354/
https://ncbi.nlm.nih.gov/pubmed/11489935
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