Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion

Studies of naturally occurring polymorphisms of the CCR5 gene have shown that deletion of the functional receptor or reduced expression of the gene can have beneficial effects in preventing HIV-1 infection or delaying disease. Because these polymorphisms are found in otherwise healthy people, strate...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Steinberger, Peter, Andris-Widhopf, Jennifer, Bühler, Bernd, Torbett, Bruce E., Barbas, Carlos F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15412/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639161/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.2.805
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