Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion

Studies of naturally occurring polymorphisms of the CCR5 gene have shown that deletion of the functional receptor or reduced expression of the gene can have beneficial effects in preventing HIV-1 infection or delaying disease. Because these polymorphisms are found in otherwise healthy people, strate...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Steinberger, Peter, Andris-Widhopf, Jennifer, Bühler, Bernd, Torbett, Bruce E., Barbas, Carlos F.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2000
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15412/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639161/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.2.805
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